Macromolecules comprising a thioether cross-link

Details Macromolecules comprising a thioether cross-link Macromolecules comprising a thioether cross-link

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) C07K 1/10 (2006.01) C07K 16/00 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2600844

The present invention provides macromolecules comprising at least one thioether cross-link. A thioether cross-link comprising a single thioether bond between two residues of a macromolecule. The macromolecules of the invention can display enhanced stability, pharmaceutical properties and functional properties. In particular, the invention provides an isolated antibodies comprising at least one thioether cross-link that specifically bind to particular antigens. The present invention also provides a composition comprising a macromolecule substantially free of a denaturing reagent, wherein the macromolecule comprises at least one thioether cross-link. In addition, the present invention provides a method for producing the macromolecules and compositions of the invention.

L'invention concerne des macromolécules comprenant au moins une réticulation de thioéther. Une réticulation de thioéther comprend un liaison de thioéther unique entre deux résidus d'une macromolécule. Les macromolécules de l'invention peuvent présenter une stabilité accrue, des propriétés pharmaceutiques améliorées et des propriétés fonctionnelles améliorées. En particulier, l'invention concerne un anticorps isolé comprenant au moins une réticulation de thioéther se liant spécifiquement à des antigènes particuliers. L'invention concerne également une composition comprenant une macromolécule sensiblement exempte d'un réactif dénaturant. Cette macromolécule comprend au moins une réticulation de thioéther. En outre, l'invention concerne une méthode pour produire ces macromolécules et les compositions de l'invention.

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