Macrophage derived chemokine (mdc) as an anti-viral agent...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/19 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C12N 15/66 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2303397

The present invention relates to therapeutic compositions of macrophage derived chemokine (MDC) and methods for treating and preventing infection by a lentivirus, particularly an immunodeficiency virus, particularly HIV, using MDC proteins, nucleic acids and/or derivatives or analogues thereof. The present invention further relates to methods for detection and prognosis of lentivirus infection, particularly HIV infection using MDC as a prognostic indicator. The present invention further provides MDC proteins, nucleic acids encoding such proteins, that have amino-terminal sequences that differ from other MDC isolates. Recombinant host cells and methods of production are also provided.

L'invention concerne des compositions thérapeutiques de chemokine dérivée d'un macrophage (MDC) et des procédés servant à traiter et à prévenir l'infection provoquée par un lentivirus, en particulier, un virus d'immunodéficience, en particulier, VIH, au moyen de protéines de MDC, de leurs acides nucléiques, de leurs dérivés ou de leurs analogues. Elle concerne, de plus, des procédés servant à détecter et à pronostiquer une infection par lentivirus, en particulier, une infection par VIH, au moyen de MDC en tant qu'indicateur de pronostic. Elle concerne également des protéines de MDC, des acides nucléiques codant ces protéines, qui possèdent des séquences à terminaison amino différentes d'autres isolats de MDC. Elle concerne également des cellules hôtes de recombinaison et des procédés de préparation.

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