Macrophage derived chemokine (mdc), mdc analogs, mdc...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/18 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2302806

The present invention provides purified and isolated polynucleotide sequences encoding a novel macrophage-derived C-C chemokine designated "Macrophage Derived Chemokine" (MDC), and polypeptide fragments and analogs thereof. Also provided are materials and methods for the recombinant or synthetic production of the chemokine, fragments, and analogs; and purified and isolated chemokine protein, and polypeptide fragments and analogs thereof. Also provided are antibodies reactive with the chemokine and methods of making and using all of the foregoing. Also provided are assays for identifying modulators of MDC chemokine activity.

Cette invention se rapporte à des séquences polynucléotidiques purifiées et isolées codant une nouvelle chémokine C-C dérivée de macrophages, appelée MDC, ainsi qu'à des fragments polypeptidiques et à des analogues de cette chémokine. Cette invention se rapporte également à des substances et à des procédés servant dans la production par recombinaison ou par synthèse de cette chémokine, de ces fragments et de ces analogues; ainsi qu'à une protéine de chémokine purifiée et isolée et à des fragments polypeptidiques et des analogues de celle-ci. Cette invention concerne également des anticorps réagissant avec cette chémokine et des procédés de production et d'utilisation correspondants. Cette invention concerne en outre des dosages permettant d'identifier des modulateurs de l'activité de chémokine de cette MDC.

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