C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07H 21/04 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2179606
There are disclosed a human macrophage inflammatory protein-3, a human macrophage inflammatory protein-4 and a human macrophage inflammatory protein- 1.gamma. polypeptides and DNA (RNA) encoding such polypeptides. There is also provided a procedure for producing such polypeptides by recombinant techniques and for producing antibodies against such polypeptides. In the invention there is also provided antagonist/inhibitors against such polypeptides which inhibit the functioning of such polypeptides. Another aspect of the invention provides a combination of the polypeptides of the present invention and a suitable pharmaceutical carrier for providing a therapeutically effective amount of the polypeptides for the treatment of various associated diseases.
Polypeptides sous forme de protéine-3 inflammatoire macrophage humaine, de protéine-4 inflammatoire macrophage humaine et de protéine-1¿.gamma.? inflammatoire macrophage humaine et ADN (ARN) codant lesdits polypeptides. Un procédé destiné à produire lesdits polypeptides par des techniques de recombinaison et à produire des anticorps contre lesdits polypeptides est décrit. La présente invention concerne également des antagonistes/inhibiteurs desdits polypeptides, qui inhibent le fonctionnement de ces derniers. Dans un autre aspect de la présente invention, une combinaison desdits polypeptides et un excipient pharmaceutique approprié permettant d'administrer une quantité pharmaceutiquement efficace desdits polypeptides pour le traitement de diverses maladies associées sont encore décrits.
Adams Mark D.
Li Haodong
Rosen Craig A.
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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