A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/60 (2006.01) A61K 31/609 (2006.01) A61P 9/00 (2006.01) C07C 65/40 (2006.01)
Patent
CA 2298824
Salicylanilide derivatives which are macrophage scavenger receptor antagonists are provided. Methods of treating cardiovascular disease comprising administration of the present compounds are also provided. The present compounds inhibit lipid accumulation within macrophage-derived foam cells.
L'invention concerne des dérivés de salicylanilide qui sont des antagonistes des récepteurs des monocytes macrophages. L'invention traite également de procédés permettant de traiter des maladies cardiovasculaires, et consistant à administrer les composés selon l'invention qui inhibent l'accumulation des lipides dans les cellules spumeuses dérivées des macrophages.
Lysko Paul G.
Weinstock Joseph
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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