C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 31/713 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2685341
Described are a method and a composition for transfecting monocytes, as well as use of the same for therapeutic purposes. The composition is composed of a nucleic acid component, a lysosome evading component and a digestible particle that can be phagocytized. Preferably, the monocyte is a macrophage and the digestible particle is from a natural source, such as from a microbial source. More preferably, the digestible particle is a yeast cell wall particle such as zymosan. The composition itself, or cells pretreated with the composition, are useful in all gene medicine applications, such as gene therapy, gene vaccination, cancer treatment as well as immunomodulation and tissue repair.
La présente invention concerne un procédé et une composition permettant la transfection de monocytes, ainsi que leur utilisation à des fins thérapeutiques. La composition comprend un composant d'acide nucléique, un composant de libération de lysosome et une particule digestible pouvant être phagocytée. Idéalement, le monocyte est macrophage et la particule digestible provient d'une source naturelle, telle une source microbienne. La particule digestible est de préférence une particule de paroi cellulaire de levure, tel le zymosan. La composition en soi, ou les cellules prétraitées avec la composition, sont utiles dans toutes les applications de médecine génétique, telles que la thérapie génique, la vaccination génique, les traitements des cancers ainsi que l'immunomodulation et la réparation tissulaire.
Schwamberger Gunter
Wagner Thomas E.
Yu Xianzhong
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Orbis Health Solutions
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