C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 11/08 (2006.01) B01D 53/04 (2006.01) B01J 20/26 (2006.01) B01J 20/28 (2006.01) B01J 20/32 (2006.01) C07K 1/22 (2006.01) C08J 9/06 (2006.01) C08J 9/26 (2006.01) G01N 33/547 (2006.01)
Patent
CA 2096224
A method to prepare uniform populations of macroscopic beads containing pores of at least 0.1 microns diameter is described. The beads consist essentially of a copolymer of a monoethylenically unsaturated monomer and a crosslinking polyethylenically unsaturated monomer, said resulting copolymer optionally being derivatized with functional groups, linking moieties, and/or affinity ligands. The macroporous beads are obtained by utilizing, as a porogen in the polymerization reaction, porous inorganic particles which have been preabsorbed with a blowing agent. The blowing agent is not activated until after the polymerization takes place; when the blowing agent is activated, the organic polymer which isolates the inorganic porogen particles from each other in the bead is destroyed. Upon subsequent dissolution of the inorganic porogen, a network of pores throughout the organic copolymer-formed particle is formed. The resulting beads are useful in a variety of chromatographic, analytical and biomedical techniques.
Li Nai-Hong
Mazid M. Abdul
Battison Williams Dupuis
Li Nai-Hong
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