Mag expression promoters

Details Mag expression promoters Mag expression promoters

C - Chemistry, Metallurgy

07

D

C07D 233/60 (2006.01) A61K 31/4174 (2006.01) A61P 25/28 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2373967

MAG expression promoters containing compounds represented by general formula (I), optically active isomers thereof or pharmaceutically acceptable salts of the same, wherein each symbol is as defined in the description. As an example of the compounds represented by the general formula (I), 4-[.alpha.-hydroxy-5- (1-imidazoyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid may be cited. These MAG expression promoters are useful as preventives and/or remedies for diseases of mammals including humans mainly presenting myelin hypoplasia and, in its turn, myelin sheath hypoplasia or myelin sheath destruction

L'invention concerne des promoteurs de l'expression de la MAG, qui renferment des composés représentés par la formule générale (I), y compris les isomères optiquement actifs ou les sels pharmaceutiquement acceptables correspondants. Dans ladite formule, chaque symbole est tel que défini aux fins de l'invention. A titre d'exemple de ce type de composé, on peut citer l'acide 4-[.alpha.-hydroxy-5-(1-imidazoyl)-2-méthylbenzyl]-3,5-diméthylbenzoïque. Les promoteurs considérés sont utiles pour la prévention et/ou le traitement de maladies affectant les mammifères, y compris l'être humain, caractérisées essentiellement par une hypoplasie de la myéline et, ensuite, une hypoplasie de la gaine de myéline ou une destruction de ladite gaine.

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