Mage-3 peptides presented by hla class ii molecules

Details Mage-3 peptides presented by hla class ii molecules Mage-3 peptides presented by hla class ii molecules

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 35/26 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) A61K 39/00 (2006.01) C07K 14/74 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2303063

The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+T lymphocytes. Methods and products are also provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.

L'invention concerne des peptides de liaison de classe II de HLA codés par le gène MAGE-3 associé à une tumeur, ainsi que des acides nucléiques codant ces peptides et des anticorps afférents. Les peptides stimulent l'activité et la prolifération de lymphocytes T CD4<+>. L'invention concerne également des méthodes et des produits destinés au diagnostic et au traitement de troubles caractérisés par l'expression du gène MAGE-3.

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