C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12N 5/08 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2443342
The invention describes HLA class II binding peptides encoded by the MAGE-A3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the MAGE- A3 gene.
La présente invention concerne des peptides de liaison HLA de classe II codés par le gène MAGE-A3 associé à la tumeur, ainsi que des acides nucléiques codant pour ces peptides et des anticorps liés à ces acides. Ces peptides stimulent l'activité et la prolifération des lymphocytes CD4?+¿ T. Cette invention concerne aussi des techniques et des produits permettant de diagnostiquer et de traiter des pathologies caractérisées par l'expression du gène MAGE-A3.
Boon-Falleur Thierry
Chaux Pascal
Van Der Bruggen Pierre
Zhang Yi
Ludwig Institute For Cancer Research
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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