Magnesium complexes of s-omeprazole

C - Chemistry – Metallurgy – 07 – D

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C07D 401/12 (2006.01) A61K 31/435 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2567356

The invention provides magnesium S-omeprazolato coordination compounds according to formula (I): [Mg(solv a)x(solv b)y][Mg(S-omeprazolato)3]2~(solv c)z (I), pharmaceutical compositions and processes of making the same. In formula (I), solv a,solv b, and solv c represent solvent molecules where x and y are independently selected from integers 0 to 6, the sum of which is 4 or 6, while z is a positive rational number from 0 to 6. The compounds are useful for the treatment of gastric acid related conditions and the inhibition of gastric acid secretion.

L'invention concerne des composés de coordination de magnésium S-omeprazolato représentés par la formule (I): [Mg(solv a)x(solv b)y][Mg(S</i>-omeprazolato)3]2 (solv c)z (I), des compositions pharmaceutiques et des procédés de production desdits composés. Dans la formule (I), solv a, solv b et solv c représentent des molécules de solvant dans lesquelles x et y sont sélectionnés indépendamment à partir de nombres entiers compris entre 0 et 6 dont la somme est 4 ou 6, z étant un nombre rationnel positif compris entre 0 et 6. Ces composés sont utilisés pour traiter des états associés à la sécrétion d'acide gastrique et pour inhiber cette sécrétion.

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