Magnetic nanoparticles compositions and uses thereof

A - Human Necessities – 61 – K

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Details

A61K 9/14 (2006.01) A61K 33/26 (2006.01) A61K 49/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2649207

The present invention relates to the use of a biocompatible nanoparticle or nanoparticle aggregate, in combination with an external non-oscillating magnetic field, wherein said nanoparticle comprises a) a core comprising magnetic material; b) a biocompatible shell surrounding the core, and, optionally, c) a labelling agent, wherein the outer diameter of the shell is less than about 100 nm, to prepare a composition, wherein the composition is deprived of any cell targeting means. The present invention further relates to the compositions thus obtained and to their uses in the field of human health, for the treatment of cancer, or in diagnostic (imaging for example), for the monitoring of tumor evolution.

La présente invention concerne l'utilisation d'une nanoparticule biocompatible ou d'un agrégat de nanoparticules, en association avec un champ magnétique non oscillant externe, en vue de préparer une composition. Ladite nanoparticule renferme : a) un noyau contenant une matière magnétique ; b) une enveloppe biocompatible entourant le noyau ; et, éventuellement, c) un agent de marquage, ledit diamètre externe de l'enveloppe étant inférieur à environ 100 nm. Ladite composition est dépourvue de tous moyens de marquage cellulaire. La présente invention concerne aussi les compositions ainsi obtenues et leurs utilisations dans le domaine de la santé destinées au traitement du cancer ou, lors d'un diagnostic (d'imagerie par exemple), à la surveillance de l'évolution d'une tumeur.

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