Magnetic nanoscale particle compositions, and therapeutic...

A - Human Necessities – 61 – F

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A61F 7/00 (2006.01) A61N 2/00 (2006.01) H01F 1/00 (2006.01)

Patent

CA 2628106

Disclosed are thermotherapeutic compositions for treating disease material, and methods of targeted therapy utilizing such compositions. These compositions comprise a) stable single domain magnetic particles; b) magnetic nanoparticles comprising aggregates of superparamagnetic grains; or c) magnetic nanoparticles comprising aggregates of stable single magnetic domain crystals and superparamagnetic grains. These compositions may also comprise a radio isotope, potential radioactive isotope, chemotherapeutic agent. These methods comprise the administration to a patient's body, body part, body fluid, or tissue of bioprobes (energy susceptive materials attached to a target-specific ligand), and the application of energy to the bioprobes so as to destroy, rupture, or inactivate the target in the patient. Energy forms, such as AMF, are utilized to provide the energy. The disclosed methods may be useful in the treatment of a variety of indications, including cancers, diseases of the immune system, central nervous system and vascular system, and pathogen-borne diseases.

L~invention concerne des compositions thermothérapeutiques pour le traitement de maladies, et des procédés de thérapie ciblée utilisant lesdites compositions. Ces compositions comprennent a) des particules magnétiques stables de simple domaine ; b) des nanoparticules magnétiques comprenant des agrégats de grains supraparamagnétiques ; ou c) des nanoparticules magnétiques comprenant des agrégats de cristaux stables de simple domaine magnétique et de grains supraparamagnétiques. Ces compositions peuvent également comprendre un radio isotope, un isotope radioactif potentiel, un agent chimiothérapeutique. Ces procédés comprennent l~administration dans le corps du patient, une partie du corps, un fluide corporel, ou un tissu de biosondes (des matériaux sensibles à l~énergie fixés à un ligand spécifique à la cible), et l~application d~énergie aux biosondes de façon à détruire, rompre ou inactiver la cible chez le patient. On utilise des formes d~énergie, comme AMF, pour fournir l~énergie. Les procédés de l~invention peuvent être utiles pour le traitement d~une variété de troubles, comme les cancers, les maladies du système immunitaire, du système nerveux centrale et du système vasculaire, et les maladies provoquées par les agents pathogènes.

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