C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 15/02 (2006.01) A61K 9/50 (2006.01) A61K 47/48 (2006.01) A61K 49/18 (2006.01) A61K 49/20 (2006.01) C07K 1/14 (2006.01) C07K 17/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2019218
The invention relates to magnetic protein conjugates of the formula I M-NH-CO-(CH2)n-S-P~~~I with n = 1-6, preferably with n = 1 or 2 and particularly preferably with n = 1, in which M is a dispersible, magnetically reacting material or particle which carries amino groups, and P is a protein, to a process for the preparation thereof and to the use thereof for the specific removal of cells or soluble antigens, receptors, substrates, cofactors or carbohydrate determinants from aqueous salt solutions or body fluids or as part of a diagnostic method or as a diagnostic aid, preferably for the removal of cells, preferably for bone marrow depletion or for HLA typing.
Donges Reiner
Enssle Karlheinz
Franssen Udo
Friesen Heinz-Jurgen
Hermentin Peter
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Dade Behring Marburg Gmbh
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