Magnetic protein conjugates, a process for the preparation...

C - Chemistry – Metallurgy – 07 – F

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23/338, 195/1.1,

C07F 15/02 (2006.01) A61K 49/18 (2006.01) A61K 49/20 (2006.01) C07K 1/22 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) C12N 9/96 (2006.01) G01N 33/543 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2019217

- 1 - Abstract of the disclosure Magnetic protein conjugates, a process for the prepara- tion thereof and the use thereof The invention relates to magnetic protein conjugates of the formula I M-NH-CO-(CH2)n-S-S-P I with n = 1-6, preferably with n = 2 or 3, in which M is a dispersible, magnetically reacting material or particle which carries amino groups, and P is a protein, to a process for the preparation thereof and to the use thereof for the specific removal of cells or soluble antigens, receptors, substrates, cofactors or carbo- hydrate determinants from aqueous salt solutions or body fluids or as part of a diagnostic method or as a diagnos- tic aid, preferably for the removal of cells, preferably for bone marrow depletion or for HLA typing.

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