Magnetic resonance blood pool agents bound to human serum...

A - Human Necessities – 61 – K

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Details

A61K 49/00 (2006.01) A61K 49/08 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2247244

The present invention provides compositions comprising a contrast agent capable of reversibly binding to thiol groups of blood-borne proteins. The compositions of the invention provide increased residence time of the contrast agent in the vasculature, thus providing effective blood pool contrast agents. The invention also provides methods for imaging a patient comprising administering a composition of the invention and obtaining an image.

Compositions comprenant un agent de contraste apte à se lier de manière réversible aux groupes thiol des protéines véhiculées par le sang. Ces compositions offrent un temps de résidence accru de l'agent de contraste dans le réseau sanguin, fournissant ainsi des agents de contraste efficaces pour le pool sanguin. L'invention porte également sur des méthodes de visualisation du corps d'un patient consistant à administrer une composition de cette invention pour obtenir l'image.

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