Magnetic resonance imaging agent containing barium sulfate...

Details Magnetic resonance imaging agent containing barium sulfate... Magnetic resonance imaging agent containing barium sulfate...

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 49/18 (2006.01) G01R 33/28 (2006.01)

Patent

CA 2163086

A negative contrast agent for MRI is an aqueous suspension having a quantity of barium sulfate between 25 and 40 percent by weight and a quantity of bentonite between two and four percent by weight. Such a negative contrast agent provides dark imaging in a T2 weighted pulse sequence; namely a relative signal intensity (RSI) approaching zero. It also provides a relative signal intensity (RSI) of under thirty percent of that of a reference that approximates tissue in a T1 weighted pulse sequence.

Un agent de contraste négatif pour imagerie par résonance magnétique (MRI) est constitué par une suspension aqueuse possédant une quantité de sulfate de barium située entre 25 et 40 % en poids et une quantité de bentonite située entre 2 et 4 % en poids. Ledit agent de contraste négatif permet d'obtenir une image sombre dans une séquence d'impulsion chargée T2, notamment, une intensité de signal relative (RSI) voisine de zéro. Il permet également d'obtenir une intensité de signal relative (RSI) inférieure à 30 % de celle d'une référence voisine du tissu dans une séquence d'impulsion chargée T1.

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