Malaria vaccine based upon the addition of a msa1 peptide

Details Malaria vaccine based upon the addition of a msa1 peptide Malaria vaccine based upon the addition of a msa1 peptide

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/70 (2006.01) A61K 39/015 (2006.01) A61K 48/00 (2006.01) C07K 14/445 (2006.01) C07K 19/00 (2006.01) C12N 15/30 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2245002

The present invention relates to a malaria chimeric peptide comprising a vaccinia virus system which expresses a protein corresponding substantially to the major merozoite surface antigen 1 (MSA1) of <u>Plasmodium</u> <u>flaciparum</u> or an immunogenic portion, thereof. In preferred embodiments, the MSA1 peptide is a 593 amino acid peptide corresponding to amino acids 1047 to 1640 of MSA1 and is combined with a signal peptide and/or an anchor peptide. Chimeric peptides having both signal and anchor sequences in combination with MSA1 sequences were the most effective in eliciting an immunogenic response from a vaccinated host.

L'invention concerne un peptide chimère de la malaria, constitué d'un système vaccinal viral qui exprime une protéine correspondant sensiblement à l'antigène majeur 1 de surface de mérozoïte (MSA1) de <u>Plasmodium</u> <u>falciparum</u> ou à une portion immunogène de celui-ci. Dans des formes d'exécution préférées, le peptide de MSA1 est un peptide à 593 aminoacides correspondant aux aminoacides 1047 à 1640 de MSA1 et il est combiné à un peptide signal et/ou à un signal d'ancrage. Les peptides chimères, ayant simultanément des séquences signal et d'ancrage associées à des séquences de MSA1, étaient particulièrement efficaces pour provoquer une réponse immune chez un hôte vacciné.

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