C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61P 15/16 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/59 (2006.01) C07K 14/705 (2006.01) C12N 15/16 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01)
Patent
CA 2449909
Disclosed are male contraceptives containing a peptide and analogs thereof having an amino acid sequence corresponding to the second extracellular domain of a mammalian occludin. The peptides may be linked to a carrier targeting testicular cells, preferably to a modified follicle stimulating hormone. Methods of producing such a contraceptive, and a method of use are also disclosed.
L'invention concerne des contraceptifs masculins renfermant un peptide et des analogues de celui-ci possédant une séquence d'acide aminé correspondant au second domaine extracellulaire d'une occludine mammifère. Les peptides peuvent être liés à un excipient ciblant des cellules testiculaires, de préférence une hormone stimulant le follicule modifiée. L'invention concerne également des procédés de fabrication d'un tel contraceptif et un procédé d'utilisation associé.
Moffat & Co.
The Population Council Inc.
LandOfFree
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