Maleate co-crystal of azd1152

Details Maleate co-crystal of azd1152 Maleate co-crystal of azd1152

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/661 (2006.01) A61P 35/00 (2006.01) C07F 9/09 (2006.01)

Patent

CA 2650519

The present invention relates to a novel co-crystal of 2-{cthyl[3-( {4-[(5- {2-[(3-fluorophenyl)amino]-2-oxoethyl}-IH-pyrazol-3-yl)amino]quinazolin-7- yl}oxy)propyl]amino} ethyl dihydrogen phosphate (AZDl 152) which is an aurora kinase inhibitor that is useful in the treatment of hyperproliferative diseases such as cancer.

La présente invention concerne un nouveau co-cristal de dihydrogéno phosphate de 2-{éthyl[3-({4-[(5-{2-[(3-fluorophényl)amino]-2-oxoéthyl}-IH-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl]amino}éthyle (AZD1 152) qui est un inhibiteur de l'aurora kinase utile dans le traitement des maladies hyperprolifératives telles que le cancer.

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