C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/404 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2702930
The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(3- pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}4-(dimethylamino)-2- butenamide, (NERATINIB) methods of preparing crystalline maleate salt forms, the associated compounds, such as its degradation and impurities and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
La présente invention porte sur des formes de sels maléates de (E)-N-{4-[3-chloro-4-(2-pyridinylméthoxy)anilino]-3-cyano-7-éthoxy-6-quinolinyl}-4-(diméthylamino)-2-buténamide, sur des procédés de préparation de formes cristallines de sels maléates, sur les composés associés, et sur des compositions pharmaceutiques les contenant. Les sels maléates sont utiles dans le traitement de cancers, en particulier ceux affectés par des kinases de la famille des récepteurs du facteur de croissance épidermique.
Cheal Gloria K.
Chew Warren
Hadfield Anthony F.
Ku Mannching Sherry
Lu Qinghong
Smart & Biggar
Wyeth Llc
LandOfFree
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