Maleic acid halfamides

Details Maleic acid halfamides Maleic acid halfamides

C - Chemistry, Metallurgy

07

D

260/515.1, 260/3

C07D 317/60 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/205 (2006.01)

Patent

CA 1108629

ABSTRACT OF THE DISCLOSURE The present invention provides hemiamides of unsatur- ated aliphatic dicarboxylic acids having the general formula Image (I) wherein R1, R2 and R3 are identical or different and represent hydrogen, a halogen atom, a hydroxy group, a methyl group or a methoxy group or two of those radicals together represent a methylene-dioxy group, R4 represents hydrogen or a methyl group, the radicals R6 and R7 represent, independently of each other, hydrogen or C1-C4-alkyl groups, and n is 0 or 1, and their salts, the N-(2-(3-hydroxy-phenyl)-2-hydroxy-ethyl)- maleic monoamide being excluded in the case of the free acids. The hemiamides have pharmacological properties.

318131

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