Malonamic acids and derivatives thereof as thyroid receptor...

Details Malonamic acids and derivatives thereof as thyroid receptor... Malonamic acids and derivatives thereof as thyroid receptor...

C - Chemistry, Metallurgy

07

C

C07C 233/01 (2006.01) A61K 31/18 (2006.01) A61K 31/196 (2006.01) A61P 5/16 (2006.01) C07C 235/16 (2006.01) C07C 235/80 (2006.01) C07C 309/29 (2006.01) C07C 311/14 (2006.01) C07C 311/29 (2006.01) C07C 317/22 (2006.01) C07D 209/46 (2006.01)

Patent

CA 2403902

The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula (I), which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesteremia, depression and osteoporosis. The present invention also provides methods, pharmaceutical compositions and kits for treating such diseases and disorders.

L'invention concerne de nouveaux ligands de récepteurs de thyroïde et, plus particulièrement, des acides malonamiques et leurs dérivés représentés par la formule (I), utiles pour le traitement de l'obésité, de l'excès de poids, de l'hyperlipidémie, du glaucome, de l'arythmie cardiaque, des troubles cutanés, des maladies thyroïdiennes, de l'hypothyroïdisme, du cancer de la thyroïde et de troubles et de maladies apparentés, tels que le diabète sucré, l'athérosclérose, l'hypertension, la maladie cardiaque coronarienne, la maladie cardiaque globale, l'hypercholestérolémie, la dépression et l'ostéoporose. Elle concerne également des procédés, des compositions pharmaceutiques et des trousses servant à traiter ces maladies et ces troubles.

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