Malonamide derivatives as gamma-secretase inhibitors

Details Malonamide derivatives as gamma-secretase inhibitors Malonamide derivatives as gamma-secretase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 223/18 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01) A61P 25/28 (2006.01) C07D 243/24 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 487/06 (2006.01)

Patent

CA 2514267

The invention relates to malonamide derivatives of formula (IA) or (IB) and to pharmaceutically suitable acid addition salts thereof. The compounds are .gamma.-secretase inhibitors and the related compounds may be useful in the treatment of Alzheimer's disease.

L'invention concerne des dérivés de malonamide représentés par la formule (IA) ou (IB) ainsi que leurs sels d'addition d'acides pharmaceutiquement acceptables. Les composés selon l'invention sont des inhibiteurs de la ?-sécrétase et les composés associés peuvent convenir au traitement de la maladie d'Alzheimer.

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