Malonic acid derivatives having antiadhesive properties

Details Malonic acid derivatives having antiadhesive properties Malonic acid derivatives having antiadhesive properties

C - Chemistry, Metallurgy

07

H

C07H 15/207 (2006.01) A61K 31/70 (2006.01) C07H 3/04 (2006.01) C07H 3/06 (2006.01) C07H 15/18 (2006.01) C07H 17/04 (2006.01)

Patent

CA 2144390

Malonic acid derivatives having antiadhesive properties The invention relates to malonic acid derivatives having antiadhesive properties, of the formula I Image I. in which R1, R2 and R3 independently of one another are H, (CH2)mX or CH2O(CH2)mX1 or R1 and R2 together form a Rix-membered carbo- or heterocycle with at least one of the sub- stituents R4, R5 and R6 and A and B independently of one another are O, S, NH, HN-CO, OC-NH, O-CO, OC-O, NH-CO-O, O- CO-NH, S-CO, SC-O, O-CS-S, S-CS-O, NH-CS- S, S-CS-NH or CH2 and Z is a pyranose, a furanose, an open-chain polyalcohol or Y-X6, Y is -O-(CX2,X3)n, -(CX2,X3)n, -(CX2,R7)n-, -(CR7,R8)n-, -CH2-(CX2,X3)-n or a saturated or unsaturated, six-membered carbo- or heterocycle having at least one substituent R9 or a combination of the chain -O-(CX2,X3)n, -(CX2,X3)n, -(CX2,R7)n-, -(CR7,R8)n- and the carbo- or heterocycle, where R4, R5 and R6 independently of one another are H, OH, (CH2)qX4, CH2O(CH2)qX5 or HNC(O)CH3 and R7, R8 and R9 independently of one another are H, OH, (CH2)qX4 or CH2O(CH2)qX5 and X, X1, x2 X3 X4 and X5 independently of one another are H, NH2, COOH, OH, CH2OH, CH2NH2, C1-C20-alkyl or C6-C10-aryl and X6 is OH or Image and m, n and q independently of one another are a number from 1 to 20, a process for their preparation, their use and pharma- ceuticals and diagnostics prepared from them.

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