C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/42 (2006.01) A61K 31/426 (2006.01) A61K 31/444 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 35/00 (2006.01) C07C 33/48 (2006.01) C07C 215/24 (2006.01) C07C 233/22 (2006.01) C07C 307/10 (2006.01) C07C 323/14 (2006.01) C07D 233/54 (2006.01) C07D 239/42 (2006.01) C07D 261/04 (2006.01) C07D 261/08 (2006.01) C07D 277/46 (2006.01) C07D 277/48 (2006.01) C07D 277/52 (2006.01) C07D 285/135 (2006.01) C07D 307/46 (2006.01) C07D 401/12 (2006.01) C07D 413/06 (2
Patent
CA 2435067
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.
La présente invention concerne des nouveaux composés (I), leurs promédicaments ainsi que des sels pharmaceutiquement acceptables et des compositions pharmaceutiques contenant ces composés, lesquels sont utiles pour traiter certaines maladies métaboliques et certaines maladies modulées par l'inhibition de l'enzyme malonyl-coenzyme A décarboxylase (malonyl-CoA, MCD). Plus particulièrement, l'invention concerne des composés et des compositions ainsi que des méthodes de prévention, de gestion et de traitement de maladies cardiovasculaires, du diabète, de l'acidose, des cancers et de l'obésité par inhibition de la malonyl-coenzyme A décarboxylase.
Arrhenius Thomas
Chen Mi
Cheng Jie Fei
Dyck Jason R.
Huang Yujin
Chugai Seiyaku Kabushiki Kaisha
Torys Llp
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