Mammaglobin, a secreted mammary-specific breast cancer protein

Details Mammaglobin, a secreted mammary-specific breast cancer protein Mammaglobin, a secreted mammary-specific breast cancer protein

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) A01N 61/00 (2006.01) A01N 63/00 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2304167

A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor.

L'invention concerne une séquence d'ADN purifiée et isolée, ainsi que la protéine sécrétée spécifique de la glande mammaire, la mammaglobine, codée par cette séquence. L'invention concerne également des procédés de dépistage du cancer du sein, sur la base de la surexpression et de la sécrétion de mammaglobine par les cellules du cancer du sein. Ces procédés permettent de détecter et/ou de quantifier la présence de la mammaglobine, ou de l'ARN messager codant celle-ci. L'invention concerne enfin des procédés de traitement par immunothérapie d'un sujet atteint du cancer du sein présentant une tumeur qui exprime la mammaglobine, ces procédés consistant à utiliser des antigènes de la mammaglobine pour induire une réponse immune humorale et/ou à médiation cellulaire contre ladite tumeur.

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