C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07K 17/00 (2006.01) C12N 15/09 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)
Patent
CA 2232239
A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as mammaglobin and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to mammaglobin-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific mammaglobin polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.
L'invention a pour objet un ensemble de séquences d'ARN contiguës et en partie imbriquées, ainsi que des polypeptides codés par celles-ci, appelées mammoglobines et transcrites à partir de tissu mammaire. Lesdites séquences servent à détecter, diagnostiquer, classer par stades, contrôler, pronostiquer, prévenir ou traiter les maladies du sein, ou encore à déterminer la prédisposition d'une personne à ces maladies ou à des états pathologiques du sein, tels que le cancer du sein. L'invention a également pour objet des anticorps se liant spécifiquement au polypeptide ou à la protéine codé(e) par mammoglobines, ces molécules étant utiles au traitement thérapeutique de maladies du sein, de tumeurs ou de métastases dans le sein.
Billing-Medel Patricia A.
Cohen Maurice
Colpitts Tracey L.
Friedman Paula N.
Gordon Julian
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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