C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2281792
The invention concerns a protein constituting a mammal neuronal amiloride sensing channel and activated by protons, and the nucleic acid molecules coding for this protein. The invention also concerns a method for screening substances capable of modulating the activity of mammal neuronal acid sensing ionic channels.
L'invention concerne une protéine constituant un canal cationique neuronal de mammifère sensible à l'amiloride et activé par les protons, ainsi que les molécules d'acide nucléique codant cette protéine. L'invention concerne aussi un procédé de criblage de substances capables de moduler l'activité de canaux ioniques neuronaux de mammifère.
Bassilana Frederic
Champigny Guy
Heurteaux Catherine
Lazdunski Michel
Lingueglia Eric
Centre National de La Recherche Scientifique
Gowling Lafleur Henderson Llp
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