Mammal prolactin variants

Details Mammal prolactin variants Mammal prolactin variants

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/22 (2006.01) C07K 14/575 (2006.01) C12N 1/21 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2472647

The invention relates to mammal prolactin (PRL) variants having a mutation or set of mutations within the 14 N-terminal amino acids thereby preventing the formation of a disulfide bridge between Cys4 and Cys11 and, a sterically hindering mutation or set of mutations within binding site 2 of PRL. These variants are useful as antagonists of mammal prolactin receptors (PRLR), more particularly of human prolactin receptor (hPRLR).

L'invention concerne des variantes génétiques de prolactine (PRL) de mammifère, qui comportent une mutation ou un ensemble de mutations dans les 14 acides aminés N-terminaux empêchant la formation d'un pont disulfure entre Cys4 et Cys11 ; et une mutation ou un ensemble de mutations produisant un encombrement stérique au site de liaison 2 de PRL. Ces variantes sont utiles comme antagonistes des récepteurs de la prolactine (PRLR) de mammifère, plus particulièrement du récepteur humain de la prolactine (hPRLR).

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