Mammalian alpha-helical protein-53

Details Mammalian alpha-helical protein-53 Mammalian alpha-helical protein-53

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C07K 16/42 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2429265

The present invention relates to polynucleotide and polypeptide molecules for mammalian alpha helix-53 (Zalpha53). The polypeptides, and polynucleotides encoding them, are hormonal and may be used to regulate the functioning of the immune system. The present invention also includes antibodies to the Zalpha53 polypeptides. Antagonists to Zalpha53 can be used to treat inflammation and inflammation-related disease.

L'invention concerne des molécules polynucléotidiques et polypeptidiques de la protéine 53 alpha hélicoïdale (Zalpha53) sécrétée par des mammifères. Les polypeptides et les polynucléotides codant pour ceux-ci sont hormonaux et sont utilisés pour réguler le fonctionnement du système immunitaire. L'invention concerne également des anticorps dirigés contre les polypeptides Zalpha53. On peut utiliser des antagonistes de Zalpha53 pour traiter une inflammation et une maladie associée à une inflammation.

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