Mammalian apoptosis inhibitor protein gene family, primers,...

Details Mammalian apoptosis inhibitor protein gene family, primers,... Mammalian apoptosis inhibitor protein gene family, primers,...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2228635

Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of additional IAP genes. In addition, methods for treating diseases and disorders involving apoptosis are provided.

L'invention concerne un type ADN sensiblement pur codant des polypeptides mammaliens (IAP), des polypeptides sensiblement purs et des procédés relatifs à l'utilisation de ce type d'ADN en vue d'exprimer les polypeptides IAP dans les cellules et chez les animaux lorsqu'il s'agit d'inhiber l'apoptose. On décrit par ailleurs des régions conservées caractéristiques de la famille des IAP ainsi que des amorces et des sondes permettant d'identifier et d'isoler des gènes IAP supplémentaires. On décrit aussi des procédés pour le traitement des affections et des troubles impliquant l'apoptose.

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