Mammalian artificial chromosome vector comprising human...

Details Mammalian artificial chromosome vector comprising human... Mammalian artificial chromosome vector comprising human...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2705841

This invention relates to a mammalian artificial chromosome vector, which retains a human chromosome 7 fragment comprising human cytochrome P450 genes and is transmittable to progeny, wherein the human chromosome 7 fragment retains a region of approximately 1 Mb ~ 500 Kb in size comprising at least a human CYP3A gene cluster, which region is located between chromosome markers AC004922 and AC073842, and to a non-human mammalian animal retaining the vector. -75-

L'invention concerne un vecteur chromosomique artificiel de mammifère qui porte un fragment de chromosome 7 humain contenant le gène de cytochrome P450 humain et qui peut être transmis aux descendants, le fragment de cytochrome 7 humain portant une région contenant au moins un groupe de gènes CYP3A humain situé entre les marqueurs chromosomiques AC004922 et AC073842 et dont la taille est d'environ 1 Mb ± 500 Kb. Elle concerne également un mammifère non humain qui porte le vecteur.

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