Mammalian cdp-diacylglycerol synthase

Details Mammalian cdp-diacylglycerol synthase Mammalian cdp-diacylglycerol synthase

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2258580

There is disclosed cDNA sequences and polypeptides having the enzyme CDP- diacylglycerol synthase (CDS) activity. CDS is also known as CTP:phosphatidate cytidylyltransferase. There is further disclosed methods for isolation and production of polypeptides involved in phosphatidic acid metabolism and signaling in mammalian cells, in particular, the production of purified forms of CDS.

La présente invention concerne des séquences d'ADNc et des polypeptides doté de l'activité enzymatique de la CDP-diacylglycérol synthétase (CDS). La CDS est également connue comme CTP, c'est-à-dire la phosphatidate cytidylyltransférase. L'invention concerne également des procédés permettant d'isoler et de produire des polypeptides impliqués dans le métabolisme et la signalisation de l'acide phosphatidique dans les cellules mammaliennes, en particulier la production de formes purifiées de la CDS.

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