Mammalian cytokine receptor - 11

Details Mammalian cytokine receptor - 11 Mammalian cytokine receptor - 11

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C12N 15/62 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2299624

Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in pancreas, small intestine, colon and thymus. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.

L'invention concerne de nouveaux polypeptides de récepteur, des polynucléotides codant pour ces polypeptides, des compositions et des procédés associés. Les polypeptides comportent un domaine extracellulaire d'un récepteur de surface qui est exprimé dans le pancréas, le petit intestin, le côlon et le thymus. Les polypeptides peuvent être utilisés dans des procédés servant à détecter des ligands activant la prolifération et/ou la différenciation de ces organes.

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