C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 38/48 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12N 15/19 (2006.01) C12N 15/57 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2332573
Purified genes from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding the polypeptides are provided. Methods of using said reagents and diagnostic kits are also provided. Characterization of genes and products relating to DC-PGT (Dendritic cell prostaglandin-like transporter), HDTEA84, HSLJD37R and RANKL (related to TNF receptor family), HCC5 chemokine, Dub 11 and Dub 12 (Deubiquitinating 11 and 12), MD-1 and MD-2 (proteins which exhibit properties of ligands for proteins exhibiting a leucine-rich protein motif (LRR)) and cyclin E2.
L'invention concerne des gènes purifiés, provenant d'un mammifère, des réactifs apparentés à ces gènes, notamment des protéines purifiées, des anticorps spécifiques et des acides nucléiques codant ces polypeptides. L'invention concerne encore des procédés d'utilisation de ces réactifs, ainsi que des nécessaires de diagnostic. Elle caractérise enfin des gènes et des produits associés à DC-PGT (transporteur du type prostaglandine de cellules dendritiques), HDTEA84, HSLJD37R et RANKL (associés à la famille des récepteurs de TNF), chimiokine HCC5, Dub 11 et Dub 12 (protéines de désubiquitination 11 et 12), MD-1 et MD-2 (protéines possédant des propriétés de ligands de protéines présentant un motif de protéine riche en leucines (LRR)) et cycline E2.
Bates Elizabeth Esther Mary
Bazan Jose Fernando
Gorman Daniel M.
Greene Jonathan R.
Hedrick Joseph A.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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