C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C12N 15/113 (2010.01) A61K 31/7088 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2251818
The present invention provides methods of identifying cellular genes necessary for viral growth and cellular genes that function as tumor suppressors. Thus, the present invention provides nucleic acids related to and methods of reducing or preventing viral infection or cancer. The invention also provides methods of producing substantially virus-free cell cultures and methods for screening for additional such genes.
La présente invention concerne des procédés d'identification de gènes cellulaires nécessaires à la croissance virale et de gènes cellulaires fonctionnant en tant qu'agents de suppression de tumeurs. Ainsi l'invention concerne des acides nucléiques associés à la régression ou à la prévention de l'infection virale ou du cancer, ainsi que des procédés visant à faire régresser ou à prévenir l'infection virale ou le cancer. L'invention concerne encore des procédés de production de cultures de cellules essentiellement dépourvues de virus, et des procédés de criblage aux fins d'isoler d'autres gènes de ce type.
Dubois Raymond N.
Organ Edward L.
Rubin Donald H.
Smart & Biggar
Vanderbilt University
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