Mammalian genes participating in circadian period

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 5/18 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2303002

A human gene and a mouse gene corresponding to Drosophila period gene which has been known as participating in the circadian period. The proteins and DNAs are applicable to the treatment of diseases relating to the circadian rhythm such as sleep stage regression syndrome, sleep stage progression syndrome, non- circadian agrypnotic syndrome, irregular agrypnotic disorder and time difference syndrome (i.e., so-called jet lag), labor and health management of those working until late at night irregularly, prevention of night poriomania in dementia, etc.

L'invention concerne un gène humain et un gène murin correspondant au gène périodique de Drosophila connu pour intervenir dans le rythme circadien. Les protéines et ADN peuvent être utilisés dans le traitement de maladies associées au rythme circadien telles que le syndrome de régression de la phase du sommeil, le syndrome de progression de la phase du sommeil, le syndrome agrypnotique non circadien, les troubles agrypnotiques irréguliers et le syndrome du décalage horaire ("jet lag"), dans le cadre de la gestion de la santé et du travail des personnes travaillant jusque tard dans la nuit de façon irrégulière et de la prévention du vagabondage nocturne associé à la démence, etc.

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