Mammalian inducible promoter cascade system

Details Mammalian inducible promoter cascade system Mammalian inducible promoter cascade system

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) C07K 14/16 (2006.01) C12N 5/16 (2006.01) C12N 5/22 (2006.01) C12N 9/72 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2041619

8/JWW 18051 TITLE OF THE INVENTION MAMMALIAN INDUCIBLE PROMOTER CASCADE SYSTEM ABSTRACT OF THE INVENTION The present invention relates to the development of a novel mammalian inducible and cascading gene expression system. Specifically, this invention relates to the development of stable host cell lines, harboring and coexpressing the retroviral transactivator protein (TAT) under the regulation of lacI/lacO, in an inducible expression system in which any cloned gene under transcriptional control of the HIV LTR promoter, can be expressed at a high level in an inducible manner.

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