Mammalian metabolites of a tachykinin receptor antagonist

Details Mammalian metabolites of a tachykinin receptor antagonist Mammalian metabolites of a tachykinin receptor antagonist

A - Human Necessities

61

K

A61K 31/535 (2006.01) A61K 31/09 (2006.01) A61K 31/121 (2006.01) A61K 31/165 (2006.01) A61K 31/192 (2006.01) A61K 31/5375 (2006.01) C07C 43/315 (2006.01) C07C 45/28 (2006.01) C07C 45/64 (2006.01) C07C 45/71 (2006.01) C07C 49/255 (2006.01) C07C 49/84 (2006.01) C07C 59/88 (2006.01) C07C 59/90 (2006.01) C07D 265/32 (2006.01) C07D 265/33 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2425908

This invention is concerned with mammalian metabolites of the compound 2-(R)- (1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)-phenyl-4-(3-(5- oxo-1H,4H-1,2,4-triazolo)methylmorpholine which is a tachykinin receptor antagonist that is useful in the prevention and treatment of certain disorders, including emesis and psychiatric disorders such as depression and anxiety.

L'invention concerne des métabolites mammifères du composé 2-(R)-(1-(R)-(3,5-bis(trifluorométhyl)phényl)éthoxy)-3-(S)-(4-fluoro)-phényl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)méthylmorpholine, lequel est un antagoniste du récepteur de la tachykinine utile dans le prévention et le traitement de certains troubles, notamment le vomissement et les troubles psychiatriques tels que la dépression et l'anxiété.

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