C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2473853
The present invention relates to isolated nucleic acid molecules conferring on mammalian carcinoma cells an ability to undergo cell migration. Recombinant DNA expression systems and host cells containing the subject nucleic acid molecule, as well as antisense oligonucleotides, are also described. Also disclosed are methods of inhibiting expresssion of the subject nucleic acid molecule, inhibiting production of the encoded protein or polypeptide, inhibiting metastasis of a carcinoma cell in a subject (including in humans), inhibiting migration of carcinoma cell in a subject, detecting the presence of a migrating carcinoma cell in a sample of a subject's tissue or body fluids, and inhibiting the migration of a placental cell into the blood stream of a female mammal.
L'invention concerne des molécules d'acides nucléiques isolées conférant aux carcinomes de mammifère une capacité à subir la migration de cellule. L'invention concerne des systèmes d'expression d'ADN de recombinaison et des cellules hôtes contenant cette molécule d'acides nucléiques, ainsi que des oligonucléotides antisens. L'invention concerne également des procédés d'inhibition de l'expression de cette molécule d'acides nucléiques, d'inhibition de la production de la protéine ou du polypeptide codé, d'inhibition de la métastase d'un carcinome chez un sujet (notamment chez l'homme), d'inhibition de la migration d'un carcinome chez un sujet, de détection de la présence d'un carcinome migrant dans un échantillon de tissus ou de fluides corporels d'un sujet, et d'inhibition de la migration d'une cellule placentaire dans le flux sanguin d'une femme.
Gowling Lafleur Henderson Llp
Texas Tech University
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