C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2252432
The present invention provides polynucleotides (mmlr-ccr or mphg-ccr) which encode novel chemokine receptors (MMLR-CCR or MPHG-CCR). The present invention provides for screening methods for the detection of molecules that modulate receptor activity. The present invention also provides for antisense molecules, diagnostic molecules, genetically engineered expression vectors and host cells for the production of purified MMLR-CCR or MPHG-CCR; antibodies, agonists, antagonists and inhibitors of MMLR-CCR or MPHG-CCR; and pharmaceutical compositions and methods of treatment based on the polypeptide, its antibodies, antagonists and inhibitors. The invention further provides diagnostic and therapeutic compositions for the detection and treatment of infection, inflammation, proliferative disease, solid tumors and cardiovascular disease.
L'invention porte: sur des polynucléotides (mmlr-ccr ou mphg-ccr) codant pour de nouveaux récepteurs de la chimoquine (MMLR-CCR ou MPHG-CCR); sur des procédés de criblage en vue de la détection de molécules modulant l'activité du récepteur; sur des molécules antisens, des molécules de diagnostic, des vecteurs d'expression obtenus par génie génétique, et des cellules hôtes servant à la production de MMLR-CCR ou MPHG-CCR purifié; sur des anticorps, agonistes, antagonistes, et inhibiteurs du MMLR-CCR ou MPHG-CCR; sur des préparations pharmaceutiques et des méthodes de traitement reposant sur le polypeptide, ses anticorps, antagonistes et inhibiteurs. Elle porte en outre sur la détection et le traitement d'infections, d'inflammations, de maladies proliférantes, de tumeurs solides, et de maladies cardio-vasculaires.
Au-Young Janice
Bandman Olga
Coleman Roger
Wilde Craig C.
Incyte Genomics Inc.
Incyte Pharmaceuticals Inc.
Smart & Biggar
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