Mammalian multipotent neural stem cells

Details Mammalian multipotent neural stem cells Mammalian multipotent neural stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) C07K 16/28 (2006.01) C12N 5/06 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2140884

The invention includes mammalian multipotent neural stem cells and their progeny and methods for the isolation and clonal propagation of such cells. At the clonal level the stem cells are capable of self regeneration and asymmetrical divi- sion. Lineage restriction is demonstrated within developing clones which are sensitive to the local environment. The inven- tion also includes such cells which are transfected with foreign nucleic acid, e.g., to produce an immortalized neural stem cell. The invention further includes transplantation assays which allow for the identification of mammalian multipotent neural stem cells from various tissues and methods for transplanting mammalian neural stem cells and/or neural or glial progeni- tors into mammals. A novel method for detecting antibodies to neural cell surface markers is disclosed as well as a monoc- lonal antibody to mouse LNGFR.

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