C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 15/12 (2006.01) C12N 15/52 (2006.01) C12Q 1/00 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2666819
The present invention relates to the competence of oocytes for uterine implantation and development into living individuals The invention more particularly relates to markers that are detected and measured in granulosa cells collected along with the oocytes during oocyte aspiration as it is done in assisted reproduction techniques Markers include cytochrome P450 aromatase (CYPl 9Al), cell division cycle 42 (CDC42), 3-.beta.-hydroxysteroid dehydrogenase 1 (3.beta.HSDl), serpm peptidase inhibitor clade E member 2 (SERPINE 2), and adrenodoxm (ADX) that are detected and measured, using RT-PCR.
L'invention concerne la compétence des ovocytes en vue de leur implantation et de leur développement utérins chez des individus vivants. L'invention concerne plus particulièrement des marqueurs qui sont détectés et mesurés dans des cellules de la granulosa collectées avec les ovocytes pendant l'aspiration des ovocytes selon les techniques de reproduction assistée. Les marqueurs comprennent cytochrome P450 aromatase (CYPl 9Al), cycle de division cellulaire 42 (CDC42), 3-.beta.-hydroxysteroide dehydrogenase 1 (3.beta.HSDl), inhibiteur de serpm peptidase clade E élément 2 (SERPINE 2) et adrenodoxm (ADX) qui sont détectés et mesurés à l'aide de RT-PCR.
Hamel Melanie
Robert Claude
Sirard Marc-Andre
Fasken Martineau Dumoulin Llp
Universite Laval
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