Mammalian peroxisome proliferator-activated receptors and...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/66 (2006.01) G01N 33/554 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2194169

Peroxisome proliferator-activated receptor subunits designated PPAR.gamma. and PPAR.delta. are described. Nucleic acid sequences encoding the receptor subunits, expression vectors containing such sequences and host cells transformed with such vectors are also disclosed, as are heterodimeric PPAR receptors comprising at least one of the invention subunits, and methods for the expression of such novel receptors, and various uses therefor.

Nouvelles sous-unités de récepteurs activés par les proliférateurs des peroxysomes, qui sont désignées par PPAR.gamma. et PPAR.delta.. Des séquences nucléotidiques codant lesdites sous-unités de récepteurs, des vecteurs d'expression contenant lesdites séquences et des cellules hôtes transformées à l'aide desdits vecteurs sont également décrites, ainsi que des récepteurs PPAR hétérodimères comprenant au moins une des sous-unités de la présente invention, des procédés d'expression desdits nouveaux récepteurs et diverses utilisations de ces récepteurs.

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