Mammalian pgrf

Details Mammalian pgrf Mammalian pgrf

C - Chemistry, Metallurgy

07

K

167/205, 530/7.1

C07K 7/04 (2006.01) A23K 1/16 (2006.01) C07K 14/60 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1247599

MAMMALIAN PGRF ABSTRACT OF THE DISCLOSURE PGRF has been synthesized. The invention provides synthetic peptides which are extremely potent in stimulating the release of pituitary GH in mammals and which have the formula: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu- Gly-Gln-Leu-Ser-Ala-Arg Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser- Arg-Gln-Gln-Gly-Glu-R34-Asn-Gln-Glu-R38-Gly-R40- R41-R wherein R is OH or NH2, R34 is Ser or Ala, R38 is Arg or Ser; R40 is Ala or Arg and R41 is Arg, Arg-Ala, Arg-Ala-Arg, Arg-Ala-Arg-Leu or des-R41. These peptides or biologically active fragments thereof, or analogs thereof having well-known substitutions and/or additions, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to mammals, including humans, and may be used diagnostically. The peptides are useful in stimulating the release of GH and accelerating growth in warm-blooded non-human animals and in improving aquiculture.

430533

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