Mammalian secretory peptide-9

Details Mammalian secretory peptide-9 Mammalian secretory peptide-9

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/42 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2294702

Novel mammalian secretory polypeptides, polynucleotides encoding the polypeptides (called Zsig9), and related compositions and methods including antibodies and antiidiotypic antibodies. Overexpression of these proteins is indicative of the presence of cancer. Antibodies and antisense nucleotides can be used therapeutically to treat the disease. Furthermore, antibodies to Zsig9 and nucleotide primers and probes can be used to diagnose the presence of tumors.

L'invention concerne de nouveaux polypeptides sécrétoires de mammifères, des polynucléotides codant pour les polypeptides (appelés Zsig9), des compositions et des procédés associés, ainsi que des anticorps et des anticorps antiidiotypes. La surexpression de ces protéines indique la présence d'un cancer. Des anticorps et des nucléotides antisens peuvent être utilisés thérapeutiquement pour traiter la maladie. De plus, des anticorps anti-Zsig9, des amorces et des sondes nucléotidiques peuvent être utilisés pour diagnostiquer la présence d'une tumeur.

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