Mammalian sweet and amino acid heterodimeric taste receptors

Details Mammalian sweet and amino acid heterodimeric taste receptors Mammalian sweet and amino acid heterodimeric taste receptors

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2452716

The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.

L'invention concerne des séquences isolées d'acide nucléique et d'acide aminé de récepteurs de goût sucré ou d'acide aminé, comprenant deux polypeptides de récepteurs hétérologues couplés à la protéine G, appartenant à la famille T1R des récepteurs couplés à la protéine G sensorielle, des anticorps correspondant à de tels récepteurs, des procédés de détection de tels acides nucléiques et de tels récepteurs, et des procédés de criblage pour des modulateurs de récepteurs de goût sucré et d'acide aminé.

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