Mammalian tolloid-like gene and protein

Details Mammalian tolloid-like gene and protein Mammalian tolloid-like gene and protein

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/51 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2253818

A mammalian gene encoding a tolloid-like protein distinct from human or murine BMP-1/mTld is presented. The gene is similar in structure to members of the BMP-1 family of genes, but maps to a distinct location and encodes a distinct protein. The protein encoded by the gene can be used to screen putative therapeutic agents in an ongoing effort to inhibit activity of the BMP-1 family of genes to prevent scarring, fibrosis, and the like.

Cette invention se rapporte à un gène mammalien codant une protéine de type tolloïde distincte de la protéine morphogénétique BMP-1 et du tolloïde mammalien mTld d'origine humaine ou murine. Ce gène possède une structure similaire à celle des éléments de la famille BMP-1 de gènes, mais il se projette en un emplacement distinct et code une protéine distincte. La protéine codée par ce gène peut servir à la sélection d'agents thérapeutiques putatifs au cours d'un processus continu destiné à inhiber l'activité de la famille BMP-1 de gènes dans le but d'empêcher la cicatrisation, la fibrose et analogue.

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