Mammalian tolloid-like gene and protein

Details Mammalian tolloid-like gene and protein Mammalian tolloid-like gene and protein

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/43 (2006.01) C07K 14/51 (2006.01) C12N 9/64 (2006.01) C12N 15/79 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2325058

A mammalian gene encoding a tolloid-like protein distinct from human or murine BMP-1/mT1d and distinct from human or murine mT11-1 is presented. The gene is similar in structure to members of the BMP-1 family of genes, but maps to a distinct location and encodes a distinct protein having distinct activities. The protein encoded by the gene can be used to screen putative therapeutic agents in an ongoing effort to inhibit activity of the BMP-1 family of genes to prevent scarring, fibrosis, and the like.

L'invention concerne un gène de mammifère codant pour une protéine de type tolloïde. Ce gène est distinct du gène BMP-1/mT1d humain ou murin et également distinct du gène mT11-1 humain ou murin. Il présente une structure similaire aux autres membres de la famille de gènes BMP-1, mais se trouve à un emplacement distinct et code pour une protéine distincte qui a des activités distinctes. La protéine codée par ce gène peut être utilisée pour la sélection d'agents thérapeutiques putatifs et contribuer ainsi à la recherche continue d'un moyen permettant d'inhiber l'activité de la famille de gènes BMP-1 afin de prévenir la formation de cicatrices, la fibrose etc.

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